ABSTRACT
Abstract Purpose: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. Methods: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. Results: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group. Conclusion: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.
Subject(s)
Animals , Male , Rats , Quercetin/analogs & derivatives , Reperfusion Injury/prevention & control , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Gastric Mucosa/injuries , Oxidation-Reduction/drug effects , Quercetin/therapeutic use , Celiac Artery/surgery , Rats, Wistar , Oxidative Stress/drug effects , Disease Models, Animal , LigationABSTRACT
Abstract Purpose: To investigate the effect of metyrosine against I/R induced gastric damage in rats. Methods: Eighteen albino Wistar male rats were divided into groups; gastric I/R (GIR), 50 mg/kg metyrosine+gastric I/R (MGIR), and sham (SG) groups. 50 mg/kg metyrosine was given to the MGIR group, and distilled water was given to the GIR and SG groups by the oral gavage. After 30 minutes, 25 mg/kg thiopental sodium was injected intraperitoneally. Ischemia was achieved for 1 hour by clamping the celiac artery of the MGIR and GIR groups, then reperfusion was achieved for 3 hours. After that, animals were killed with 50 mg/kg thiopental. Biochemical and histopathological examinations performed on the gastric tissues. Results: Metyrosine decreased the MDA and MPO and the increased the tGSH and SOD. In addition, it reduced inflammation by suppressing the decrease of COX-1 and the increase of COX-2. Histopathologically, metyrosine decreased symptoms caused by I/R such as mucosal necrosis, hemorrhage, edema, PMNL infiltration, and dilated congested blood vessels. Conclusions: Metyrosine prevented the I/R induced oxidative stress in the gastric tissue. Metyrosine may be beneficial for gastric I/R injury.
Subject(s)
Animals , Male , Rats , Reperfusion Injury/complications , Oxidative Stress/drug effects , alpha-Methyltyrosine/administration & dosage , Enzyme Inhibitors/administration & dosage , Gastric Mucosa/metabolism , Time Factors , Rats, Wistar , Disease Models, Animal , Gastric Mucosa/pathologyABSTRACT
Although gallbladder cancers are rarely seen, the mortality rates are high. Pure squamous cell cancer, which is one of the most rarely seen cancer types in the gallbladder, originates from the squamous metaplasia which forms following chronic irritation in the mucosa. The majority of cases are generally at the inoperable stage when diagnosed as they have been followed up for long-term cholelithiasis. The case is here presented of a 59-year old female who underwent surgical and medical treatment for a bladder tumour 10 years previously and although gallbladder stones were determined at that time, as she was asymptomatic, surgery was not recommended, then with the progression of time, gallbladder squamous cell carcinoma developed.
ABSTRACT
Paraganglioma occur from the paraganglionic stems of the autonomic nervous system. They develop from the carotid body and are known as carotid body tumours. These are sporadic, rare vascular lesions showing genetic transfer. Although they are generally benign and have a slow course, because of invasion to adjacent neurovascular tissues or pressure, early diagnosis and treatment is of importance. Diagnosis is made from a detailed history and physical examination and is confirmed with angiography. The treatment method selected in the majority of cases is surgery. In this paper, the case is presented of a 73-year old female who underwent surgery in our clinic for a diagnosis of carotid body paraganglioma.
ABSTRACT
Eccrine porocarcinoma is a very rarely seen malignant skin tumour which originates from the intra-epithelial section of the eccrine sweat glands. They are generally seen in the elderly and are most often located in the lower extremities. This tumour which has a poor prognosis and displays different biological behaviour, often has a tendency to recurrence and metastasis is seen in the skin and lymph nodes. The basis of treatment is surgical excision and if there is lymph node involvement, regional lymph node dissection must be applied. The case is here presented of a 67-year old patient with eccrine porocarcinoma which developed in the inguinal region and showed recurrence.